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However, their clinical translation is often limited by poor bioavailability and inadequate tumor targeting

For example, Bisphenol A (BPA) and formaldehyde are the widespread environmental pollutants, both of which can cause male reproductive injuries including testicular histopathological changes (decreased spermatogenic cells (144) or testicular tissue necrosis and edema (145)), testicular oxidative stress damage(reducing testicular antioxidant enzyme activity (197)) and cells apoptosis(up-regulating Bax apoptotic protein expression (145))

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5.2 Calibration The osmometer should be calibrated as per the manufacturer's instructions using either purchased or prepared Standard Solutions (as described in Table 1)