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J stroke cerebrovascular Dis

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Enrichment and functional reconstitution of glutathione transport activity from rabbit kidney mitochondria: further evidence for the role of the dicarboxylate and 2-oxoglutarate carriers in mitochondrial glutathione transport

Furthermore, a separate study confirmed the involvement of ferroptosis in the pathogenesis of epilepsy associated with mitochondrial disease and revealed that alpha-tocotrienol quinone (EPI-743) effectively ameliorated ferroptosis in cells derived from patients with five distinct childhood epilepsy syndromes in a dose-dependent manner by reducing lipid peroxidation (LPO) and 15-hydroxyditetraenoic acid (15-HETE) levels (17)