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Many companies are beginning clinical trials to understand the role of senolytics in improving age-related diseases [68]

The therapeutic era of peptides began in 1921 with the discovery of insulin, a breakthrough that revolutionized diabetes and helped establish biologic therapies in medicine 1 Since then, peptide hormones like oxytocin and human growth hormone (GH) have entered clinical use, and glucagon-like peptide-1 (GLP-1) receptor agonists such as semaglutide are now widely prescribed for obesity and metabolic diseaseconditions increasingly recognized for their effect on orthopaedic outcomes

Explant area and mean pixel intensity value corrected by the background signal were quantified to provide either the area of Calcein-AM-stained axons over a specified threshold or Calcein-AM fluorescence intensity per unit of area

However, these were predominantly mild to moderate and transient