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This indicated an enhancement in Bcl-2 expression, a reduction in Bax expression, a reversal of high PARP activity and caspase-3 levels, and a decrease in phosphorylated JNK and p38 expression (Lu et al
Cancer Inf
Although important risks and hazards are associated with using these delivery particles, particularly from the long-term perspective [142], bilirubin nanoparticles have indisputable therapeutic potential, especially with the development of new self-generated and self-enhanced biodegradable materials in this rapidly evolving field [143]
