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In summary, the AMPK-mTOR signaling pathway mediates autophagy activation through the regulation of key factors such as Sestrin2 and TFE3, playing an important role in alleviating ERS and oxidative stress, and promoting neuroprotection

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Further, we test whether this decline in proteostasis and A processing can be restored in primary neurons from aged mice by treatment with nicotinamide to boost NAD + levels and with EGCG to engage Nrf2 signaling and redox balance
