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Sci Rep 12:4634

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Mechanistic studies reveal that SFN significantly downregulates programmed death-ligand 1 (PD-L1) expression on tumor cells through multiple mechanisms, including direct covalent modification of cysteine residues on STAT1, which inhibits its transcriptional activity and blocks IFN--induced PD-L1 expression (75)

Tirzepatide is a fascinating synthetic peptide, a dual GIP and GLP-1 receptor agonist
