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This interplay suggests that mitochondria-centered metabolic reprogramming may contribute to cellular senescence not only through alterations in metabolic pathways or metabolites but also by influencing cellular signaling and gene expression through mitochondrial enzymes and metabolites

However, due to more frequent resistance to dopamine agonists (DAs) therapy (10, 11), the larger tumor diameter (4, 5), and the need for radiation therapy (4144) or surgical intervention, PRLoma management in men may become challenging

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