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Prasad AS, Meftah S, Abdallah J, Kaplan J, Brewer GJ, Bach JF, et al
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[33] Placebo-controlled trials have been deemed unethical in instances where not receiving treatment may lead to harm for the patient, such as an aggravation of symptoms or risk of death
For this review, we will use biochemical signaling to refer to the binding of vascular endothelial growth factor (VEGF) to VEGF receptor 2 (VEGFR-2), while biomechanical signaling will refer to VEGFR-2 activation or downstream signaling induced by non-ligand binding cues
