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Short-term storage at 28C is acceptable for active research periods but will shorten overall shelf life and is not recommended once the vial has been opened

A retrospective study looking at concomitant use of proton pump inhibitors (PPIs) alongside metformin in 614 people with type 2 diabetes in the US found a significant reduction in B12 levels of 34% in patients taking both medications, compared to controls taking either drug alone (Long et al, 2012)

J Endocrinol 204(1):1 Baerlocher MO, Asch M, Myers A (2013) Metformin and intravenous contrast

Progress photos in consistent lighting and posture, taken every 2-4 weeks, reveal changes that gradual daily observation misses