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However, in contrast to conventional drugs, RR does not lead to drug dependence or addiction, nor does it surpass the bodys stress defence ability or hinder its ability to return to a normal state of functioning once the drugs effects have subsided [30]

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These findings indicate that lipid peroxidation products like 4-HNE contribute to high-fatinduced cardiomyocyte damage and that activation of the AMPK signaling pathway may serve as a protective mechanism against such oxidative stress (Yun et al., 2025)

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