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Ketamine is reported to produce mitochondrial dysfunction and oxidative stress that further lead to cause psychosis in mice [2]

Lack of 12/15-lipoxygenase (or its human homolog 15-lipoxygenase) was not sufficient to disrupt reticulocyte maturation (Sun and Funk, 1996)

This and many other hitherto uncharacterised factors induce accumulation of pathogenic inclusions differently termed as Lewy bodies in neurons of PD patients (Marotta et al., 2021) or glial cytoplasmic inclusions in oligodendrocytes of Multiple System Atrophy (MSA) patients (Reddy and Dieriks, 2022)

However, not everyone absorbs vitamin B12 efficiently