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2.2 Lipid peroxidation The sensitivity of ferroptosis is closely related to lipid metabolism and directly affects the biosynthesis and storage of lipid peroxidation (Yang and Stockwell, 2016)

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Similarly, some flavonoids have proven tendency for binding to benzodiazepine site on the GABA A receptor [18, 19 and also act as an scavenger to pro-inflammatory and neurotoxic species [20]

However, perturbing metabolic pathways in leukaemic blasts alone is not efficient enough to improve clinical outcomes and reduce the relapse rate in patients