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Fecal elimination of metabolites also occurs, particularly following oral administration, though quantitative contribution of each elimination pathway varies by route and dose

158,159,160 Additionally, other post-translational modifications, including truncation, 161,162 glycosylation, 163 glycation, 164 and sumoylation, 165 play an active role in promoting tau aggregation and increasing its toxicity

The list of the cysteine modifications used in our database search strategy is indicated in the methods