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They are intricately linked to cell-specific adjustments in response to metabolic stress, and disruptions in these signaling pathways are closely associated with various pathological conditions (88)

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Compatible solutes can be accumulated at high concentrations in the cytoplasm while not interfering with cellular processes, and thus contribute to proper protein function and cellular homeostasis (Brown & Simpson, 1972)

The normal intracellular concentrations of carnitine are very much higher than that in plasma - muscle carnitine is some 50-fold higher than plasma carnitine, and in liver the concentration is more than 10,000-times that in plasma