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[DOI] [PMC free article] [PubMed] [Google Scholar] 92.Nabavi S.F., Braidy N., Gortzi O., Sobarzo-Sanchez E., Daglia M., Skalicka-Woniak K., Nabavi S.M

Chronic HG has been linked to advanced glycation end products AGEs formation, which in turn activates intracellular signaling and promotes the expression of pro-inflammatory transcription factors and the release of various inflammatory cytokines (93)

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The authors believed the metabolic changes they found likely extend to the entire immune system, and if systemic, could explain the prevalence of fatigue and other symptoms in these two syndromes