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The zebrafish modelcharacterized by high-throughput screening capacity, optical transparency, genetic tractability, and cost efficiencyis rapidly transitioning from a basic research tool to a pivotal platform bridging mechanistic investigation and clinical translation (Figure 5A) (Patton et al., 2021

There was evidence of cochleotoxicity in 165 medications (evidence grading A [22], B [77], C [69]) and vestibulotoxicity in 100 medications (evidence grading A [23], B [47], and C [30]), where the evidence grades were as follows: grade A (randomized, controlled clinical trials), grade B (nonrandomized clinical trials, prospective observational studies, cohort studies, retrospective studies, case-controlled studies, or postmarketing surveillance studies), and grade C (case reports/case series)

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It may be formed as part of the hyperplastic response