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Mason RP, Casu M, Butler N et al (2013) Glutathione peroxidase activity is neuroprotective in models of Huntingtons disease

The CC genotype of rs20417 is associated with a higher incidence of oxidative stress ( Nitric oxide synthase The family of nitric oxide synthase (NOS) proteins, which includes neuronal NOS ( nNOS or NOS 1 ), inducible NOS ( iNOS or NOS 2 ), and endothelial NOS ( eNOS or NOS 3 ), plays a crucial role in catalyzing the oxidation of L-arginine, producing NO and L-citrulline (Supplementary Figure S1)

Four isoforms of human glutaminase are divided into two highly active renal glutaminase types encoded by GLS1 and two low active hepatic glutaminase types encoded by GLS2

This patient's lack of primary gastrointestinal malignancies and presence of a parafollicular cell neoplasm make a DNA mismatch repair gene mutation unlikely