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Despite this, total body weight, food intake and serum levels of GH and IGF-1 remain similar to those in the vehicle-treated Uni-Nx group, suggesting direct renal effects.29 In contrast, continuous infusion of IGF-1 during one-week results in increased glomerular volume and decreased renal vascular resistance, leading to a higher GFR

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treated hESCs with Wnt/-catenin inhibitor IWR-1 together with activin A and noggin, resulting in induction of PFG gene expression (Touboul et al., 2016), although noggin was later found to impede with the promoting effect of IWR-1 on PFG induction