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187 In a cell line of human mast cells (LAD2 cells), TriHOME formation is LOX-independent and yields a 13( R ) configuration, whereas in eosinophils this synthesis is initiated by 15-LOX, resulting in a 13( S )-configuration

The overexpression of adenovirus-mediated TIGAR not only reduced infarct volume, but also inhibited the decline of glial fibrillary acidic protein (GFAP) 24 h after reperfusion, reduced long-term mortality significantly and improved the recovery of neurological function in vivo , while TIGAR knockout had the opposite effect (Chen et al., 2018)

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The glutamate analog kainic acid (KA) has been used in many mammals to induce status epilepticus (KA-SE) through its neuroexcitatory and neurotoxic effects (Nadler and Kainic, 1981)