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446 However, pathological effects emerge when immune clearance fails, leading to senescent cell accumulation and SASP-driven fibrosis in the tissue microenvironment

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The supernatant was used for the analysis of LPO (Reference Ledwozyw, Michalak and Stepie25) , nitric oxide (NO) (Reference Miranda, Espey and Wink26) , GSH (Reference Beutler27) , glutathione-S-transferase (GST) (Reference Habig and Jakoby28) , SOD (Reference Mylroie, Collins and Umbles29) and tissue factor (TF) (Reference Ingram30) activities

HepG2-derived microsomes and EPR spectroscopy allowed us to confirm the formation of the NFT radical anion (Fig