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Increased TRAP signal demonstrates enzymatic activity it does not, on its own, demonstrate that any organisms somatic-cell telomeres will lengthen in vivo, that lengthened telomeres translate to delayed senescence in tissue, or that delayed senescence in tissue translates to extended organismal lifespan

Due to the pathologic implication of oxidative stress in FRDA, attempts have been and are being made to develop drugs which can counteract the impact of oxidative stress in FRDA

For these characteristics, ATRA was considered as a novel therapeutic strategy for AD treatment, as an additional alternative to the vitamin A supplement