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As an essential component of the innate immune repertoire of the CNS, this inflammation is typically mediated by the resident immune cells of the CNS, microglia, in concert with astrocytes, microvascular endothelial cells and peripheral immune cells that can migrate into the CNS

Proc Soc Exp Biol Med 215:314332 Garg S, Malhotra RK, Khan SI, Sarkar S, Susrutha PN, Singh V, Goyal S, Nag TC, Ray R, Bhatia J, Arya DS (2019) Fisetin attenuates isoproterenol-induced cardiac ischemic injury in vivo by suppressing RAGE/NF-B mediated oxidative stress, apoptosis and inflammation

We will examine the consequences of mtDNA dysfunction for immune cell fate and systemic inflammation, discuss the clinical relevance of mtDNA as a biomarker for toxicity and disease progression, and highlight emerging therapeutic strategies aimed at preserving mitochondrial health to improve the long-term well-being of PLWH