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In addition, after ex vivo stimulation with phorbol myristate acetate (PMA)/ionomycin, IFN-, granzyme B (GzB), and perforin expression were increased post-dose in several participants, with significant changes being detected in CD8 + T cells for GzB and perforin ( n = 5, Fig

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591,592 Interestingly, the pathological shift arises not from loss of native function but from a toxic gain of function through aggregation, illustrating that even minor perturbations in protein stability can drive systemic disease

Signal containment: The sheath prevents electrical signals from leaking out of the axon, preserving signal strength and direction