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Studies have found that simultaneous deletion of PTEN and SOCS3 enables sustained axon regeneration in CNS (Sun et al., 2011) and the overexpression of astrocytic PTEN alleviates neuropathic pain (Fang et al., 2022)

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Even more, it has recently been postulated that the restriction of DNA synthesis to the reductive phase of the cycle in yeast may be an evolutionarily important mechanism for reducing oxidative damage to DNA during replication [51], which implies the common mechanism of the DNA protection during S phase in all eukaryotes

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