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The CBS gene is located on chromosome 21q22.3 and is composed of 23 exons which generate five alternatively spliced mRNAs that collectively encode two distinct proteins of 551 amino acids (isoform 1) and 446 amino acids (isoform 2)

Aside from providing cysteine as a glutathione precursor, NAC also appears to have antioxidant properties by itself, and is a valuable sulfur donor for various metabolic needs

The 5mC and 5hmC immunoprecipitation signals were determined using gene-specific primers (Supplementary Table 1)

Upon activation, these T cells release interferon- (IFN-), which downregulates neuronal expression of ferritin heavy chain (FTH1), resulting in increased intracellular labile iron, thereby enhancing susceptibility to ferroptosis