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This creates constant energy demand, leading to a massive influx of oxygen and the production of reactive oxygen species (ROS) that can damage the very cellular machinery that powers the cell

This leads to the accumulation of autophagy receptor proteins like p62 and impairs HDAC6-mediated retrograde transport as well as exocytotic disposal of misfolded proteins

10.5505/tjtes.2017.25730 20 FranchiS.GianniniE.LattuadaD.LattanziR.TianH.MelchiorriP.et al (2008)

Gut microbiota in human metabolic health and disease
