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As a side note, the observed modest response for the DMSO control was also incorporated into the model to take into account that a minor part of the pathway activation observed under the experimental conditions used is due to DMSO rather than DEM (see Supplement)

Macrophages first store iron intracellularly, mostly in ferritin (Ft) complexes

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Increasing evidence implicates oxidative stress (OS) with age-related neurodegeneration, neurotoxicity, and neuronal loss [12]
