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Loss of DNA mismatch repair in acquired resistance to cisplatin

Rapid upregulation of genes involved in the glutathione (GSH) metabolism pathway supported maintenance of GSH pools and increases in intracellular succinate in seal but not human cells during hypoxia exposure

Together with IL-12 and IL-18 or transforming tumor necrosis growth factor (TGF)-, IL-6, and IL-23, TNF- induces the differentiation of nave CD4+ T cells into pro-inflammatory T helper cells of type 1 (T H 1) and type 17 (T H 17), respectively [6,12,13]