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Prolonged overdose of B6 (150-200 mg/day) over weeks can cause severe sensory-nervous-system dysfunction and ataxia.37 With normal usage serious adverse effects are not reported for pyridoxine (vitamin B6), however, diarrhoea, emesis and rosacea-like dermatitis may be observed in some cases (38)

Expected timeline: Week 1-4: Inflammation reduction, potential nerve symptom improvement Week 4-8: Progressive healing, reduced radicular symptoms Week 8-12: Structural improvements developing, continued symptom reduction Week 12-16: Consolidation of gains, assessment for continued protocol Important notes: Disc herniations vary enormously in severity

In fact, a retrospective study has shown that higher expression of CD38 on tumor-infiltrating plasma cells correlates with increased disease-free survival and overall survival [49]

- Ensure the units billed exactly match the dosage given, as documented in the MRI procedure note