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518,519 In addition, in pediatric UC patients, when treated with low-dose or high-dose vedolizumab on day 1 and at weeks 2, 6, and 14, respectively, significant efficacy was similarly demonstrated

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IV doses of 25-400 mcg/kg for safety studies Important: These are experimental doses used in animal studies and cannot be extrapolated to other species due to significant differences in metabolism, pharmacokinetics, receptor expression, peptide degradation rates, and tissue distribution patterns

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