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The revised PI states, "Hemophagocytic lymphohistiocytosis (HLH) has occurred in pediatric and adult patients taking Lamictal for various indications

Taken together, our results establish the SPOC domain as an essential module for PHF3 and DIDO interaction with the Pol II transcription elongation machinery, whereas SHARP and RBM15 SPOC show stronger binding to other proteins

3.2.5 Individual Bioavailability Estimates The model was used to obtain individual bioavailability estimates for each subject and each dose administration