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i represents for the selected enzyme, k for the regression coefficient and x for the log2(FPKM + 1) expression level

Although the FDA has approved both purified VEGF and fibroblasts to accelerate closure of non-healing wounds, sustained expression and a long half-life of the growth factors were not outstanding in these approaches 9

Both routes have a place
Sci Rep 7:44055 Dalle-Donne I, Rossi R, Colombo G, Giustarini D, Milzani A (2009) Protein S-glutathionylation: a regulatory device from bacteria to humans