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10.1016/j.febslet.2015.04.041
Xie X, Zhao M, Huang S, Li P, Chen P, Luo X

Unlike memory T cell differentiation in acute immune responses, exhausted T cells in GBM fail to sustain long-term antitumor immunity due to persistent antigen exposure, metabolic stress, and an immunosuppressive TME

For example, the SOD1 inhibitor tetrathiomolybdate (ATN-224) protects PTPs from oxidation, and this, in turn, attenuates growth factormediated phosphorylation of ERK1/2 in endothelial and tumor cells (Juarez et al., 2008)
