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This gene cluster includes a dihydrodiol dehydrogenase ( phtB) , a multi-component dioxygenase containing large ( phtAa ) and small (phtAb) subunits, a ferredoxin ( phtAc ) and a reductase ( phtAd ), apart from a decarboxylase ( phtC ) and an IcIR-type regulator ( phtR )

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Relevant pharmacokinetic parameters for dihexa as determined after IV dosing are summarized in Table 9

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