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While M2 polarization is supposed to enhance tissue repair, during chronic infections, M2-like macrophages can promote tissue fibrosis, neoplasia and impair Th1 responses, thus promoting pathogen persistence and associated tissue pathology [97]

All patients have held their improvements, without a return of severe symptomology

Contrarily, in bile duct occluded rats, in an 8-week study [118], BPC 157 was given continuously (intraperitoneally once a day or perorally (continuously in drinking water)) or only once as a direct bath application

The uniform cement distribution in BFMCs may compromise local mechanical strength, whereas the high-density cement clusters in PKP may be more suitable for high-load areas