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Autophagy 18, 703704
Interestingly, PRX5, the closest animal orthologue to ancestral PRXQ, appears to have been lost in several species that exhibit gene expansion of subfamily AhpC-PRX1
This does not invalidate the findings, but it means the evidence base is not yet at the level of FDA-approved pharmaceuticals
For the next two decades, liver was the main source of this unknown extrinsic factor
