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Unfortunately, after 2 to 3 years, resistance starts to develop in PC against ADT, which is then become castration-resistant prostate cancer (CRPC) (Zhang et al
[DOI] [PubMed] [Google Scholar] 127.Schagen S
Similarly, CTLA-4 and FR4 are expressed on Treg cells
doi: 10.1016/j.brainres.2006.06.042
