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Recently, by using the SPEAC technique with co-culture of cells in drops and CRISPR-Cas induced genetic manipulation, Wheeler and collaborators (153) identified the amphegulinIL33-ST2 pathway as another communication mechanism between microglia and astrocytes, relevant to the pathogenesis of MS

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Moreover, in recent years, many minimally invasive or noninvasive techniques have been incorporated into AR, such as microbubble-assisted ultrasound, which combines ultrasound with microbubbles in the middle ear, and the new magnetic/acoustic dual-controlled microrobot, which can efficiently transport medications to the inner ear without damaging the ear tissues, making the treatment and rehabilitation of hearing impairment more effective (Yi et al., 2024