is selenium is part of the glutathione peroxidase enzyme system Simplified catalytic mechanism peroxidase: in the The role of selenium metabolism

Gaiday AN, Tussupkaliyev AB, Bermagambetova SK, et al

Michalski N, Goutman JD, Auclair SM, Boutet de Monvel J, Tertrais M, Emptoz A, Parrin A, Nouaille S, Guillon M, Sachse M, Ciric D, Bahloul A, Hardelin J-P, Sutton RB, Avan P, Krishnakumar SS, Rothman JE, Dulon D, Safieddine S, Petit C

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Under pro-inflammatory conditions, as evidenced by interventions with LPS or IFN-, microglia are insensitive to ferroptosis, yet susceptible to iron overload ( in vitro data showed that genetic depletion of iNOS renders Raw264.7 cells and EOC 20 cells vulnerable to ferroptosis, whereas NO donors (SNAP, DPTA-NONOate) empower the ferroptotic resistance of M2 microglia ( The sophisticated interplay between neuroinflammation, instigated by microglia in response to inflammatory stimuli, and ferroptosis in microglia has been documented