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However, low to moderate levels of ROS can promote cancer cell survival and metastasis pathways through DNA damage-induced genomic instability, epigenetic regulation, metabolic reprogramming, and generation of pro-inflammatory and pro-tumorigenic microenvironment in a context-dependent manner [8, 12, 13, 26]

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One peptide, LC * YDPDFEK (Cys115 in GSTM2), was found only through DDA efforts, which was based on susceptibility of MRM transitions to isobaric interferences

Histological examination Histological analysis of the skin was performed by taking 6 mm diameter biopsy punches from areas of interest