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Collectively, these findings support the notion that LPCAT3 serves not only as a core lipid remodeling enzyme in the ferroptosis cascade but also as a disease-specific modulator of immune-metabolic interactions in OA
Each peptide targets different but complementary mechanisms, with KPV adding potent anti-inflammatory activity through NF-B inhibition

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Currently, the only FDA-approved medication for ischemic stroke is alteplase, a tissue plasminogen activator (tPA) [86]
