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siRNA-mediated silencing of NRF2 (Supplementary Figure S6A) rendered PC9 cells erlotinib resistant, a change associated with lower intracellular GSH (Figure 3c and d)

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As inflammation becomes chronic, IL-6 emerges as a secondary pleiotropic mediator whose elevation reflects sustained upstream cytokine activation rather than an initial trigger of disease [24, 25]

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