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We present six stories, discussing changes in sensitivity or resistance to azoles, cisplatin, oxidative stress, arginine biosynthesis perturbations, DNA synthesis inhibitors, and tamoxifen, to demonstrate the power of this novel methodology to broadly profile changes due to gene mutations

Comparative analysis with other emerging modalities, including monoclonal antibodies, GLP-1 analogs, gene editing tools, and microbiome modulators, suggests that integrated strategies combining nanotechnology with molecular inhibition may offer the most effective path forward

doi: 10.3389/fphar.2024.1422686 185 PawlukH.WoniakA.GrzekG.KoodziejskaR.KozakiewiczM.KopkowskaE.et al

In recent decades, with rapid advances in molecular biology and genomics, we have achieved an unprecedented understanding of the cellular response and molecular mechanisms involved in liver repair and regeneration