loren pickart ghk-cu Super GHK Copper GHK-Cu Topical Serum: Benefits, Mechanism

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The skin-specific mechanisms of GHK-Cu include stimulation of Type I and Type III procollagen synthesis, increased production of dermatan sulfate and other glycosaminoglycans, activation of the enzyme lysyl oxidase (which cross-links newly formed collagen), reduction of matrix metalloproteinase-1 (MMP-1, collagenase) activity, and anti-inflammatory suppression of TNF-alpha-induced IL-6 secretion

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One study 5 found a cumulative incidence of psoriasiform dermatitis of 1.1% at 1 year, 6.75% at 5 years, and 28.9% at 10 years in a cohort of patients with inflammatory bowel disease treated with TNF alpha inhibitors