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On the other hand, the expression of anti-inflammatory cytokines such as IL-10 is promoted by sulforaphane, as shown in senescent astrocytes [108], the LPS-activated C6 astrocyte cell line [116], and human monocyte-derived dendritic cells [76]

Genetic mapping of the major genes controlling GST-based DDT resistance in provided however evidence for a trans-acting regulator [84], although in this species, mutations in promoter elements of the Epsilon GST cluster are also associated with resistance [81]

Circulation 145, e895e1032

To further test the role of GCL in modulating glutathione and glutamate, we utilized sulforaphane, which increases GCL expression through activation of the Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) pathway (22)