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Bioavailability refers to the proportion of a nutrient that enters the circulation and is able to have an active effect

doi: 10.3389/fimmu.2025.1593263 Received 13 March 2025 Accepted 26 June 2025 Published 21 July 2025 Volume 16 - 2025 Edited by Rajko Reljic, University of London, United Kingdom Reviewed by Angelo Izzo, Royal Prince Alfred Hospital, Australia Angel Alejandro Oate, University of Concepcion, Chile Premanshu Dandapat, Indian Council of Agricultural Research (ICAR), India Updates Copyright 2025 Almujri, Stylianou, Nicastri, Satti, Korompis, Li, De Voss, Polo Peralta Alvarez, Tanner, Bettencourt, Ternette and McShane

Limitations : Risk of hypothyroidism requiring lifelong hormone replacement, delayed therapeutic effects, and potential worsening of ophthalmopathy

Studies have been done on L-Carnitine since 1937