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Role of mTORC1 in the sensing of defective mitochondria mTORC1 contributes to the detection of defective mitochondria not only by regulating organelle dynamics and isolating damaged organelles through fission but also by modulating communication with the nucleus via retrograde signaling, particularly when the mitochondrial genome needs to be repaired (Fig

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Mitochondrial dysfunction Mitochondrial dysfunction has been well-documented in ME/CFS at rest, with reported impairments in electron transport chain (ETC) activity and reduced ATP synthesis 33,34,35 , although not all studies have reported these findings 36

Lipid-lowering effect of berberine in human subjects and rats