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Through ATF4-mediated integrated stress responses, cancer cells acquire not only drug persistence, ferroptosis sensitivity, and also metastatic phenotype 45,46,47
The cytoplasmic reduction of disulfide bonds is achieved by the thioredoxin superfamily which includes the glutaredoxin proteins along with glutathione
A novel SHP-1/Grb2-dependent mechanism of negative regulation of cytokine-receptor signaling: contribution of SHP-1 C-terminal tyrosines in cytokine signaling
