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In this case, metformin has shown anti-angiogenic effects in a rotenone-induced model of PD which has been correlated to the neuroprotection of TH + neurons in the substantia nigra (El-Ghaiesh et al., 2020)
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There is a higher chance of damage in digestion, which can cause bloating, or nausea, particularly at high doses
These observations have generated interest in gastrointestinal research, although clinical confirmation remains limited
