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It uses a methyl group donated by S-adenosylmethionine (SAM) to methylate nicotinamide a vitamin B3 form that would otherwise be recycled back into NAD+

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Shi, H., Chapman, N

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In rodents, ER signaling can also exert anti-oxidative stress effects to resist Nrf2 signaling dysfunction [191]

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Role of RBP2-induced ER and IGF1R-ErbB signaling in tamoxifen resistance in breast cancer

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